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Identification of a single amino acid required for APOBEC3 antiretroviral cytidine deaminase activity.
Dang, Ying; Abudu, Aierken; Son, Sungmo; Harjes, Elena; Spearman, Paul; Matsuo, Hiroshi; Zheng, Yong-Hui.
Afiliação
  • Dang Y; Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, Michigan, USA.
J Virol ; 85(11): 5691-5, 2011 Jun.
Article em En | MEDLINE | ID: mdl-21430060
ABSTRACT
During studies of APOBEC3 (A3) anti-human immunodeficiency virus type 1 (anti-HIV-1) mechanisms, we identified a single cysteine at position 320 (C320) that disrupts A3DE activity. This residue is located in the recently identified DNA binding domain in A3G. Replacing C320 with a corresponding tyrosine from A3F (Y307) increased A3DE antiviral activity more than 20-fold. Conversely, replacing A3F Y307 with a cysteine or inserting a similar cysteine into A3B or A3G disrupted the anti-HIV activity of A3. Further investigation uncovered that C320 significantly reduces A3DE catalytic activity.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: HIV-1 / Cisteína / Citidina Desaminase / Citosina Desaminase Tipo de estudo: Diagnostic_studies Limite: Humans Idioma: En Ano de publicação: 2011 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: HIV-1 / Cisteína / Citidina Desaminase / Citosina Desaminase Tipo de estudo: Diagnostic_studies Limite: Humans Idioma: En Ano de publicação: 2011 Tipo de documento: Article