ß-Adducin is required for stable assembly of new synapses and improved memory upon environmental enrichment.
Neuron
; 69(6): 1132-46, 2011 Mar 24.
Article
em En
| MEDLINE
| ID: mdl-21435558
ABSTRACT
Learning is correlated with the assembly of new synapses, but the roles of synaptogenesis processes in memory are poorly understood. Here, we show that mice lacking ß-Adducin fail to assemble new synapses upon enhanced plasticity and exhibit diminished long-term hippocampal memory upon environmental enrichment. Enrichment-enhanced the disassembly and assembly of dynamic subpopulations of synapses. Upon enrichment, stable assembly of new synapses depended on the presence of ß-Adducin, disassembly involved ß-Adducin phosphorylation through PKC, and both were required for augmented learning. In the absence of ß-Adducin, enrichment still led to an increase in spine structures, but the assembly of synapses at those spines was compromised. Virus-mediated re-expression of ß-Adducin in hippocampal granule cells of ß-Adducin(-/-) mice rescued new synapse assembly and learning upon enrichment. Our results provide evidence that synapse disassembly and the establishment of new synapses are both critically important for augmented long-term learning and memory upon environmental enrichment.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Sinapses
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Proteínas de Ligação a Calmodulina
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Hipocampo
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Memória
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Plasticidade Neuronal
Limite:
Animals
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article