Structural feature of bent DNA recognized by HMGB1.
J Am Chem Soc
; 133(15): 5788-90, 2011 Apr 20.
Article
em En
| MEDLINE
| ID: mdl-21443191
ABSTRACT
High Mobility Group Box 1 (HMGB1) protein, a potential therapeutic target, binds bent DNAs structure-specifically. Here we report on a crucial structural feature of the bent DNA required for strong binding to HMGB1. NMR structures of two bent DNA oligomers, only one of which binds strongly to HMGB1, revealed that the presence of a pocket structure on the minor groove is crucial for strong binding through penetration of a phenylalanine residue.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
DNA
/
Proteína HMGB1
Limite:
Humans
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article