Molecular recognition force spectroscopy: a new tool to tailor targeted nanoparticles.
Small
; 7(9): 1236-41, 2011 May 09.
Article
em En
| MEDLINE
| ID: mdl-21456083
ABSTRACT
The density of targeting moieties in a nanoparticle-based gene-delivery system has been shown to play a fundamental role in its vectoring performance. Here, molecular recognition force spectroscopy is proposed as a novel screening tool to optimize the density of targeting moieties of functionalized nanoparticles towards attaining cell-specific interaction. By tailoring the nanoparticle formulation, the unbinding event probability between nanoparticles tethered to an atomic force microscopy tip and neuronal cells is directly correlated to the nanoparticle gene-vectoring capacity. Additionally, new insights into protein-receptor interaction are revealed. This novel approach opens new avenues in the field of nanomedicine.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Microscopia de Força Atômica
/
Nanotecnologia
/
Nanopartículas
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article