Response of fetal rat calvarial cells to nanotubular titanium oxide surface.
J Nanosci Nanotechnol
; 11(2): 1807-10, 2011 Feb.
Article
em En
| MEDLINE
| ID: mdl-21456297
ABSTRACT
This study examined the cell response to a TiO2 nanotubular surface (Ti-NT) for future biomedical applications. The level of cell attachment and spreading at 20 min and 60 min was evaluated by SEM. IL-6 and PGE2 secretion was evaluated by ELISA. In SEM analysis, the Ti-NT surface had more fully spread cells compared to the machined titanium surface (Ti-S). ELISA revealed that the level of IL-6 and PGE2 production was higher on the Ti-NT than on the Ti-S. These results suggest that a surface treatment with a nanotubular TiO2 surface enhances the early osteoblast responses, such as cell spreading and cytokine release, which are important for subsequent cell functions and bone healing in vivo.
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Base de dados:
MEDLINE
Assunto principal:
Crânio
/
Titânio
/
Nanotubos
Limite:
Animals
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article