The discovery of novel 8-azabicyclo[3.2.1]octan-3-yl)-3-(4-chlorophenyl) propanamides as vasopressin V1A receptor antagonists.
Bioorg Med Chem Lett
; 21(10): 3163-7, 2011 May 15.
Article
em En
| MEDLINE
| ID: mdl-21458261
ABSTRACT
The discovery of a novel series of 8-azabicyclo[3.2.1]octan-3-yl)-3-(4-chlorophenyl) propanamide antagonists of the vasopressin V(1A) receptor is disclosed. Compounds 47 and 48 were found to be high affinity, selective vasopressin V(1A) antagonists.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Descoberta de Drogas
/
Antagonistas dos Receptores de Hormônios Antidiuréticos
/
Amidas
Limite:
Humans
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article