Interleukin 3 induces histamine synthesis in the human hemopoietic system.
Exp Hematol
; 18(11): 1158-63, 1990 Dec.
Article
em En
| MEDLINE
| ID: mdl-2146139
Recombinant human interleukin 3 (rhIL-3) induces an increase in histamine production by human bone marrow, fetal liver, and cord blood cells. This phenomenon, already significant after 3 days of incubation, is strikingly enhanced following either enrichment in immature cell subpopulations or CD8+ cell depletion. It results from an increase in histamine synthesis because of 1) the low level of histamine cell content before any incubation, 2) the parallel increase in both extra- and intracellular histamine levels in response to rhIL-3, and 3) the early IL-3-induced increase in L-histidine decarboxylase (HDC; EC 4.1.1.22) activity. Moreover, rhIL-3 has no similar activity on adult peripheral blood cells, suggesting that it might be specific to the hemopoietic system.
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Base de dados:
MEDLINE
Assunto principal:
Células-Tronco Hematopoéticas
/
Histamina
/
Interleucina-3
Limite:
Adult
/
Humans
Idioma:
En
Ano de publicação:
1990
Tipo de documento:
Article