Controlling and switching the morphology of micellar nanoparticles with enzymes.
J Am Chem Soc
; 133(22): 8392-5, 2011 Jun 08.
Article
em En
| MEDLINE
| ID: mdl-21462979
ABSTRACT
Micelles were prepared from polymer-peptide block copolymer amphiphiles containing substrates for protein kinase A, protein phosphatase-1, and matrix metalloproteinases 2 and 9. We examine reversible switching of the morphology of these micelles through a phosphorylation-dephosphorylation cycle and study peptide-sequence directed changes in morphology in response to proteolysis. Furthermore, the exceptional uniformity of these polymer-peptide particles makes them amenable to cryo-TEM reconstruction techniques lending insight into their internal structure.
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Base de dados:
MEDLINE
Assunto principal:
Proteínas Quinases Dependentes de AMP Cíclico
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Metaloproteinase 2 da Matriz
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Metaloproteinase 9 da Matriz
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Nanopartículas
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Proteína Fosfatase 1
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Micelas
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article