[Effects of different excipients on properties of Tongsaimai mixture and pellet molding].

OBJECTIVE: To study preliminarily on the relationship between properties of the mixture composed of Tongsaimai extract and different excipients and pellet molding. METHOD: The multivariate regression analysis was used to investigate the correlation of different mixture and pellet molding by measuring the cohesion, liquid-plastic limit of mixture, and the powder properties of pellets. The weighted coefficients of the powder properties were determined by analytic hierarchy process combined with criteria importance through intercriteria correlation. RESULT: The results showed that liquid-plastic limit seemed to be a major factor, which had positive correlation with pellet molding, while cohesion had negative correlation with pellet molding in the measured range. CONCLUSION: The physical properties of the mixture has marked influence on pellet molding.