Whole-genome sequences of four Mycobacterium bovis BCG vaccine strains.

Pan, Yuanlong; Yang, Xi; Duan, Jia; Lu, Na; Leung, Andrea S; Tran, Vanessa; Hu, Yongfei; Wu, Na; Liu, Di; Wang, Zhiming; Yu, Xuping; Chen, Chen; Zhang, Yuanyuan; Wan, Kanglin; Liu, Jun; Zhu, Baoli

Pan, Yuanlong; Yang, Xi; Duan, Jia; Lu, Na; Leung, Andrea S; Tran, Vanessa; Hu, Yongfei; Wu, Na; Liu, Di; Wang, Zhiming; Yu, Xuping; Chen, Chen; Zhang, Yuanyuan; Wan, Kanglin; Liu, Jun; Zhu, Baoli.

Afiliação

Pan Y; Microbial Genome Research Center, CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, People's Republic of China.

J Bacteriol ; 193(12): 3152-3, 2011 Jun.

Article em En | MEDLINE | ID: mdl-21478353

ABSTRACT

ABSTRACT

Mycobacterium bovis Bacille Calmette-Guérin (BCG) is the only vaccine available against tuberculosis (TB). A number of BCG strains are in use, and they exhibit biochemical and genetic differences. We report the genome sequences of four BCG strains representing different lineages, which will help to design more effective TB vaccines.

Assuntos

Vacina BCG; Genoma Bacteriano; Mycobacterium bovis/classificação; Mycobacterium bovis/genética; Deleção de Genes; Duplicação Gênica; Regulação Bacteriana da Expressão Gênica/fisiologia; Variação Genética; Dados de Sequência Molecular

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Vacina BCG / Genoma Bacteriano / Mycobacterium bovis Idioma: En Ano de publicação: 2011 Tipo de documento: Article

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