Synthesis and evaluation of a bimodal CXCR4 antagonistic peptide.
Bioconjug Chem
; 22(5): 859-64, 2011 May 18.
Article
em En
| MEDLINE
| ID: mdl-21480671
ABSTRACT
The antagonistic Ac-TZ14011 peptide, which binds to the chemokine receptor 4, has been labeled with a multifunctional single attachment point reagent that contains a DTPA chelate and a fluorescent dye with Cy5.5 spectral properties. Flow cytometry and confocal microscopy showed that the bimodal labeled peptide gave a specific receptor binding that is similar to monofunctionalized peptide derivatives. Therefore, the newly developed bimodal peptide derivative can be used in multimodal imaging applications.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Peptídeos
/
Quelantes
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Receptores CXCR4
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Ácido Pentético
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Corantes Fluorescentes
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article