Pyridine inhibitor binding to the 4Fe-4S protein A. aeolicus IspH (LytB): a HYSCORE Investigation.
J Am Chem Soc
; 133(17): 6525-8, 2011 May 04.
Article
em En
| MEDLINE
| ID: mdl-21486034
ABSTRACT
IspH is a 4Fe-4S protein that carries out an essential reduction step in isoprenoid biosynthesis. Using hyperfine sublevel correlation (HYSCORE) spectroscopy, we show that pyridine inhibitors of IspH directly bind to the unique fourth Fe in the 4Fe-4S cluster, opening up new routes to inhibitor design, of interest in the context of both anti-bacterial as well as anti-malarial drug discovery.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Piridinas
/
Bactérias
/
Proteínas de Bactérias
/
Proteínas Ferro-Enxofre
/
Antibacterianos
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article