Complement activation: a critical mediator of adverse fetal outcomes in placental malaria?
Trends Parasitol
; 27(7): 294-9, 2011 Jul.
Article
em En
| MEDLINE
| ID: mdl-21493146
ABSTRACT
Malaria infection is a significant risk factor for low birth weight outcomes in pregnancy. Despite efforts to define the molecular mechanisms that cause low birth weight as a result of intrauterine growth restriction, the roles of inflammation and mononuclear cells in the process are incompletely understood. Data from adverse pregnancy outcomes in humans and from murine models of pathological pregnancies suggest that C5a could be an important upstream regulator of placental angiogenesis, and excessive C5a could lead to functional placental insufficiency by impairing adequate vascularization of the placenta. Based on recent evidence, we hypothesize that complement factor C5a is a central initiator of poor birth outcomes associated with placental malaria by promoting mononuclear cell migration, activation and dysregulated angiogenesis.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Placenta
/
Resultado da Gravidez
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Complicações Parasitárias na Gravidez
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Ativação do Complemento
Tipo de estudo:
Prognostic_studies
/
Risk_factors_studies
Limite:
Female
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Humans
/
Pregnancy
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article