Cancer of the gastrointestinal tract results in a restricted T-cell repertoire dependent upon tumor differentiation.
Cell Immunol
; 270(1): 47-52, 2011.
Article
em En
| MEDLINE
| ID: mdl-21497799
ABSTRACT
We investigated the influence of tumor tissue differentiation on the diversity of TCR repertoire. CDR3 spectratypes of CD4(+) and CD8(+) T cell subsets were analyzed from 27 patients with gastrointestinal tract tumors exhibiting varying degrees of differentiation. A CDR3 spectratype complexity scoring system was used to quantify the diversity of TCR repertoire. Each patient was matched with an age-matched healthy group to control for age variability. Results show that the complexity scores (TCR repertoire diversity) have a significant correlation with the degree of tumor differentiation, which provides useful information for understanding immune response in cancer patients.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Retais
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Neoplasias Gástricas
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Complexo Receptor-CD3 de Antígeno de Linfócitos T
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Neoplasias do Colo
Limite:
Adult
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Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article