Immunologic considerations for generating memory CD8 T cells through vaccination.
Cell Microbiol
; 13(7): 925-33, 2011 Jul.
Article
em En
| MEDLINE
| ID: mdl-21501363
ABSTRACT
Following infection or vaccination, naïve CD8 T cells that receive the appropriate integration of antigenic, co-stimulatory and inflammatory signals undergo a programmed series of biological changes that ultimately results in the generation of memory cells. Memory CD8 T cells, in contrast to naïve cells, more effectively limit or prevent pathogen re-infection because of both qualitative and quantitative changes that occur following their induction. Unlike vaccination strategies aimed at generating antibody production, the ability to generate protective memory CD8 T cells has proven more complicated and problematic. However, recent experimental results have revealed important principles regarding the molecular and genetic basis for memory CD8 T cell formation, as well as identified ways to manipulate their development through vaccination, resulting in potential new avenues to enhance protective immunity.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Vacinas
/
Vacinação
/
Linfócitos T CD8-Positivos
/
Memória Imunológica
Tipo de estudo:
Qualitative_research
Limite:
Humans
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article