Anaplastic lymphoma kinase in human cancer.
J Mol Endocrinol
; 47(1): R11-23, 2011 Aug.
Article
em En
| MEDLINE
| ID: mdl-21502284
ABSTRACT
The receptor tyrosine kinases (RTKs) play a critical role, controlling cell proliferation, survival, and differentiation of normal cells. Their pivotal function has been firmly established in the pathogenesis of many cancers as well. The anaplastic lymphoma kinase (ALK), a transmembrane RTK, originally identified in the nucleophosmin (NPM)-ALK chimera of anaplastic large cell lymphoma, has emerged as a novel tumorigenic player in several human cancers. In this review, we describe the expression of the ALK-RTK, its related fusion proteins, and their molecular mechanisms of activation. Novel tailored strategies are briefly illustrated for the treatment of ALK-positive neoplasms.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Receptores Proteína Tirosina Quinases
/
Linfoma
Limite:
Humans
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article