Immune escape from HIV-specific antibody-dependent cellular cytotoxicity (ADCC) pressure.
Proc Natl Acad Sci U S A
; 108(18): 7505-10, 2011 May 03.
Article
em En
| MEDLINE
| ID: mdl-21502492
ABSTRACT
Effective immunity to HIV is poorly understood. In particular, a role for antibody-dependent cellular cytotoxicity (ADCC) in controlling HIV is controversial. We hypothesized that significant pressure from HIV-specific ADCC would result in immune-escape variants. A series of ADCC epitopes in HIV-infected subjects to specific consensus strain HIV peptides were mapped using a flow cytometric assay for natural killer cell activation. We then compared the ADCC responses to the same peptide epitope derived from the concurrent HIV sequence(s) expressed in circulating virus. In 9 of 13 epitopes studied, ADCC antibodies were unable to recognize the concurrent HIV sequence. Our studies suggest ADCC responses apply significant immune pressure on the virus. This result has implications for the induction of ADCC responses by HIV vaccines.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Células Matadoras Naturais
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Ativação Linfocitária
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Infecções por HIV
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HIV-1
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Citotoxicidade Celular Dependente de Anticorpos
Limite:
Humans
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article