Epicardial adipose tissue is an independent marker of cardiovascular risk in HIV-infected patients.
AIDS
; 25(9): 1199-205, 2011 Jun 01.
Article
em En
| MEDLINE
| ID: mdl-21505301
ABSTRACT
BACKGROUND:
Epicardial adipose tissue (EAT) is increased in HIV-infected patients. The aim of this study was to evaluate the association between EAT and coronary artery calcium (CAC) a marker of atherosclerosis; furthermore, we investigated the association of EAT with HIV infection, antiretroviral therapy (ART), and lipodystrophy.METHODS:
This was a cross-sectional study of 876 consecutive HIV-infected ART experienced patients. Patients underwent CAC imaging with multidetector computed tomography (CT) for atherosclerosis screening and risk of cardiovascular events (CAC score >100); EAT was measured in the same CT images. Factors independently associated with EAT were explored in a multivariable backward stepwise linear regression analysis. Multivariable logistic regression was used to evaluate the association of EAT and CAC score greater than 100.RESULTS:
Patients' mean age was 47.2 ± 8 years, 68% were men. EAT was associated with central fat accumulation and mixed lipodystrophy phenotypes. Factors independently associated with EAT were age [ß = 0.6, confidence interval (CI) 0.2-1.0], male sex (ß = 6.6, CI 0.5-12.7), visceral adipose tissue (ß = 0.12, CI 0.08-0.17), waist circumference (ß = 0.7, CI 0.04-1.3), current CD4⺠(ß = 0.6, CI 0.1-1.2, per 50 cells), total cholesterol (ß = 0.1, CI 0.02-0.15), and cumulative exposure to ART (months) (ß = 0.05, CI 0.00-0.11). EAT (per 10 cm³) was associated with CAC greater than 100 (odds ratio = 1.10, CI 1.02-1.19) after adjustment for age, male sex, and diabetes.CONCLUSION:
We showed an association between EAT and central fat accumulation and mixed form lipodystrophy phenotypes as well as traditional risk factors for atherosclerosis. EAT may be a useful marker of cardiovascular risk as shown by its association with CAC greater than 100.
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Pericárdio
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Doenças Cardiovasculares
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Infecções por HIV
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Tecido Adiposo
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Síndrome de Lipodistrofia Associada ao HIV
Tipo de estudo:
Etiology_studies
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Observational_studies
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Prevalence_studies
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Risk_factors_studies
Limite:
Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article