Concise synthesis of the C-1-C-12 fragment of amphidinolides T1-T5.
Org Biomol Chem
; 9(13): 4823-30, 2011 Jul 07.
Article
em En
| MEDLINE
| ID: mdl-21509362
ABSTRACT
The C-1-C-12 segment of the amphidinolides T1-T5 has been synthesised in an efficient manner. The key transformations are highly diastereoselective rearrangement of an oxonium ylide, or metal-bound ylide equivalent, produced by intramolecular reaction of a copper carbenoid with an allylic ether, and macrocyclic fragment coupling by one-pot ring-closing metathesis and hydrogenation.
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Base de dados:
MEDLINE
Assunto principal:
Macrolídeos
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article