Solar urticaria treated with intravenous immunoglobulins.
J Am Acad Dermatol
; 65(2): 336-340, 2011 Aug.
Article
em En
| MEDLINE
| ID: mdl-21514688
ABSTRACT
BACKGROUND:
Solar urticaria (SU) is a rare idiopathic photodermatosis induced immediately after sun exposure. This disorder may considerably restrict normal daily life and management is extremely difficult when treatment with oral H1 antihistamines and sun avoidance are ineffective.OBJECTIVE:
We sought to report the effectiveness of intravenous immunoglobulins (IVIG) in severe SU.METHODS:
We performed a retrospective multicentric study via the mailing of a questionnaire to the French photodermatology units to analyze all cases of patients with SU who were treated with IVIG.RESULTS:
Seven patients (5 women) with a mean age of 40 years (range 32-55 years) and a mean disease duration of 5 years (range 2-10 years) received IVIG. The administration schedule differed from one patient to another 1.4 to 2.5 g/kg were infused over 2 to 5 days. Five of 7 patients obtained a complete remission. The number of courses necessary to obtain clinical remission varied from 1 to 3 courses. Complete remission was maintained during 4 to more than 12 months but antihistamines were still required. In one case, psoralen plus ultraviolet A photochemotherapy was administered.LIMITATIONS:
Retrospective study design, limited number of patients, and variations in the IVIG administration schedule could limit the interpretation of the results.CONCLUSION:
Our case series suggests a beneficial effect of IVIG in severe SU but additional prospective trials including a larger number of patients are needed to demonstrate the effectiveness of IVIG and to specify the optimal modalities of their administration in this disease.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Transtornos de Fotossensibilidade
/
Luz Solar
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Urticária
/
Imunoglobulinas Intravenosas
Tipo de estudo:
Etiology_studies
/
Incidence_studies
/
Observational_studies
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Prognostic_studies
/
Risk_factors_studies
Limite:
Adult
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Female
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Humans
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Male
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Middle aged
País como assunto:
Europa
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article