The Fok1 vitamin D receptor gene polymorphism is associated with plasma renin activity in Caucasians.
Clin Endocrinol (Oxf)
; 74(6): 783-90, 2011 Jun.
Article
em En
| MEDLINE
| ID: mdl-21521263
ABSTRACT
OBJECTIVES:
25-Hydroxyvitamin D (25(OH)D) deficiency and excess activity of the renin-angiotensin system (RAS) are both associated with cardiovascular disease. Vitamin D interacts with the vitamin D receptor (VDR) to negatively regulate renin expression in mice; however, human studies linking genetic variation in the VDR with renin are lacking. We evaluated (i) whether genetic variation in the VDR at the Fok1 polymorphism was associated with plasma renin activity (PRA) in a population of hypertensives and a separate population of normotensives and (ii) whether the association between Fok1 genotype and PRA was independent of 25(OH)D levels. DESIGN/PATIENTS/MEASUREMENTS Genetic association study, assuming an additive model of inheritance, of 375 hypertensive and 146 normotensive individuals from the HyperPATH cohort, who had PRA assessments after 1 week of high dietary sodium balance (HS) and l week of low dietary sodium balance (LS).RESULTS:
The minor allele (T) at the Fok1 polymorphism was significantly associated with lower PRA in hypertensives (LS ß = -0·22, P < 0·01; HS ß = -0·19, P < 0·01); when repeated in normotensives, a similar relationship was observed (LS ß = -0·17, P < 0·05; HS ß = -0·18, P = 0·14). In multivariable analyses, both higher 25(OH)D levels and the T allele at Fok1 were independently associated with lower PRA in hypertensives; however, 25(OH)D was not associated with PRA in normotensives.CONCLUSIONS:
Genetic variation at the Fok1 polymorphism of the VDR gene, in combination with 25(OH)D levels, was associated with PRA in hypertension. These findings support the vitamin D-VDR complex as a potential regulator of renin activity in humans.
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Base de dados:
MEDLINE
Assunto principal:
Renina
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Receptores de Calcitriol
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Polimorfismo de Nucleotídeo Único
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População Branca
Tipo de estudo:
Etiology_studies
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Observational_studies
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Prevalence_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Adult
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article