Protective effect of ε-viniferin on ß-amyloid peptide aggregation investigated by electrospray ionization mass spectrometry.
Bioorg Med Chem
; 19(10): 3152-5, 2011 May 15.
Article
em En
| MEDLINE
| ID: mdl-21524590
ABSTRACT
Abnormal ß-amyloid peptide accumulation and aggregation is considered to be responsible for the formation and cerebral deposition of senile plaques in the brains of patients with Alzheimer's disease (AD). Inhibition of the formation of ß-amyloid (Aß) fibrils would be an attractive therapeutic target for the treatment of AD. Resveratrol and its derivatives exhibit a broad range of pharmacological properties such as protection against cardiovascular diseases and cancers, as well as promoting antiaging effects. We reported previously that ε-viniferin glucoside (VG), a resveratrol-derived dimer, strongly inhibits Aß (25-35) fibril formation in vitro. In this study, we investigated the effects of VG on the aggregation of the full-length peptides (Aß (1-40) and Aß (1-42)) and on the ß-amyloid-induced toxicity in PC12 cells. VG inhibited Aß cytotoxicity and the non-covalent complex between VG and Aß was observed by electrospray ionization mass spectrometry.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Estilbenos
/
Benzofuranos
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Peptídeos beta-Amiloides
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Vitis
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article