Increased HDAC in association with decreased plasma cortisol in older adults with chronic fatigue syndrome.
Brain Behav Immun
; 25(8): 1544-7, 2011 Nov.
Article
em En
| MEDLINE
| ID: mdl-21549189
ABSTRACT
Hypocortisolism is a frequent finding in individuals with chronic fatigue syndrome (CFS) with other research findings implying potential dysregulation of glucocorticoid signaling. Glucocorticoid signaling is under the influence of several pathways, several of which are of interest in the study of CFS. Oxidative stress and decreased antioxidant capacity are known to disrupt the hypothalamic-pituitary-adrenal (HPA) axis (Epel et al., 2004) and the presence of histone deacetylases (HDAC) could also impact glucocorticoid signaling. The intent of this pilot study was to investigate the relationship among oxidative stress elements, select HDAC's (2/3) and glucocorticoid receptor signaling in an elderly sample with CFS. Findings suggest increased histone deacetylase activity, lower total antioxidant power, in the context of decreased plasma cortisol and increased plasma dehydroepiandrosterone concomitant with decreased expression of the encoding gene for the glucocorticoid receptor. These findings support the presence of HPA axis dysregulation in elderly individuals with CFS.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Hidrocortisona
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Síndrome de Fadiga Crônica
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Histona Desacetilases
Tipo de estudo:
Risk_factors_studies
Limite:
Aged
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Aged80
/
Female
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Humans
/
Male
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article