Part 3: Design and synthesis of proline-derived α2δ ligands.
Bioorg Med Chem Lett
; 21(12): 3771-3, 2011 Jun 15.
Article
em En
| MEDLINE
| ID: mdl-21550802
ABSTRACT
A potent series of substituted (2S,4S)-benzylproline α(2)δ ligands have been designed from the readily available starting material (2S,4R)-hydroxy-L-proline. The ligands have improved pharmacokinetic profile over the (4S)-phenoxyproline derivatives described previously and have potential for development as oral agents for the treatment of neuropathic pain. Compound 16 has been progressed to clinical development.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Prolina
/
Desenho de Fármacos
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article