Endocytic trafficking and Wnt/ß-catenin signaling.
Curr Drug Targets
; 12(8): 1216-22, 2011 Jul 01.
Article
em En
| MEDLINE
| ID: mdl-21561414
ABSTRACT
Several mechanisms function in the endocytic regulation of the Wnt/ß-catenin signaling pathway to promote or interrupt the progression of critical cellular processes during embryonic development or disease progression. Endocytosis was initially associated with the formation of a morphogen gradient of Wnt/ß-catenin signaling, but current studies have documented its role in defining signal intensity and propagation. Although the exact parameters that define and dictate the internalization of Wnt receptors and co-receptors via clathrin- or caveolae-mediated endocytosis remain unclear, new studies indicate that the trafficking of the signaling pool of the dual-function protein beta-catenin from sites of cell-cell contacts serve as a mechanism to finely tune the outcome of the Wnt/ß-catenin signaling. This review discusses the endocytic regulation of Wnt/ß-catenin signaling that occurs at the cell surface as well as within the cell.
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Base de dados:
MEDLINE
Assunto principal:
Proteínas Wnt
/
Beta Catenina
Limite:
Humans
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article