[Association between aggressive behaviors and COMT Val158Met and 5-HTTLPR polymorphisms in children].
Zhongguo Dang Dai Er Ke Za Zhi
; 13(5): 361-4, 2011 May.
Article
em Zh
| MEDLINE
| ID: mdl-21575337
ABSTRACT
OBJECTIVE:
To investigate the association between aggressive behaviors and catechol-O-methyltransferase (COMT) single nucleotide polymorphism at position 158 from a valine to a methionine (Val158Met) as well as serotonin (5-HT) transporter gene linked polymorphic region (5-HTTLPR) in children.METHODS:
A total of 68 children who were exposed to domestic violence were recruited. The frequencies of genotypes and alleles of COMT Val158Met and 5-HTTLPR were examined by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) techniques. A comparison was conducted between 24 children with high scores of aggressive problems and 44 control children with low scores of aggressive problems according to Child Behavior Checklist (for parents).ResultsThere were no significant differences in genotypes of COMT Val158Met (χ2=1.612, P=0.447) and 5-HTTLPR (χ2=1.807, P=0.405) between the two groups. There were also no significant differences in the frequencies of alleles of COMT Val158Met (χ2=1.648, P=0.119) and 5-HTTLPR(χ2=0.403, P=0.527) in the two groups.CONCLUSIONS:
COMT Val158Met and 5-HTTLPR might not be the susceptible genes of children's aggression, suggesting that children's aggressive behaviors might be affected by multivariate factors.
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Base de dados:
MEDLINE
Assunto principal:
Polimorfismo Genético
/
Catecol O-Metiltransferase
/
Agressão
/
Proteínas da Membrana Plasmática de Transporte de Serotonina
Tipo de estudo:
Risk_factors_studies
Limite:
Adolescent
/
Child
/
Female
/
Humans
/
Male
Idioma:
Zh
Ano de publicação:
2011
Tipo de documento:
Article