Molecular lesion frequency of hemoglobin gene disorders in Taiwan.
Hemoglobin
; 35(3): 228-36, 2011.
Article
em En
| MEDLINE
| ID: mdl-21599435
ABSTRACT
Hemoglobin (Hb) gene disorders are common inherited diseases in Taiwan. The α- and ß-thalassemias are among the well-known Hb diseases in this area. We reviewed abnormal hematological data in 3578 cases, identified between 1998 and 2009, as being at-risk for α-thalassemia (α-thal) (n = 1909; 53.3%), ß-thal (n = 743; 20.8%), non-α, ß-thal (n = 872; 24.4%), and α-thal combined with ß-thal (n = 54; 1.5%), and collected fetal blood samples for prenatal testing. The most common types of α(0)- and α(+)-thal were the SEA (Southeast Asian) deletion and the -α(3.7) rightward deletion, with frequencies of 87.79 and 4.85%, respectively. The frequency of the IVS-II-654 (C>T) mutation, the most common ß-thal mutation in this region, was 38.6%. Hb E [ß26(B8)GluâLys, GAG>AAG] was found to be the most common Hb variant, and it was concluded that Hb Tak [ß147 (+AC)], Hb G -Taichung (also known as Hb Q-Thailand) [α74(EF3)AspâHis, GAC>CAC (α1)], Hb Owari [α121(H4)ValâMet (GTG>ATG)], and Hb Phnom Penh [α117(GH5)Phe-Ile-α118(H1)Thr (α1)] were very rare. The results of this study provide a primary reference for designing a locally relevant antenatal diagnostic test for controlling the spread of thalassemia.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Talassemia
/
Hemoglobinas Anormais
/
Deleção de Sequência
/
Hemoglobinopatias
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
Limite:
Female
/
Humans
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Male
/
Pregnancy
País como assunto:
Asia
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article