Lithium: a modulator of cyclic AMP-dependent events in lymphocytes?
Science
; 203(4378): 365-7, 1979 Jan 26.
Article
em En
| MEDLINE
| ID: mdl-216075
ABSTRACT
Theophylline, salbutamol, isoproterenol, and dibutyryl cyclic AMP inhibited E-rosette formation by human T lymphocytes and immunoglobulin M secretion from human plaque-forming B cells and augmented T-suppressor cell activity in three patients with agammaglobulinemia. Lithium chloride increased mitogen-induced lymphocyte proliferation and inhibited suppressor cell activity. In the presence of lithium, the effects of all the drugs except dibutyryl cyclic AMP could be prevented. The data suggest a role for lithium in the modulation of cyclic AMP-dependent events in lymphocytes. Its potential role as an inhibitor of suppressor cell activity warrants further attention.
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Base de dados:
MEDLINE
Assunto principal:
Formação de Roseta
/
Linfócitos
/
Terapia de Imunossupressão
/
AMP Cíclico
/
Lítio
/
Formação de Anticorpos
Limite:
Humans
Idioma:
En
Ano de publicação:
1979
Tipo de documento:
Article