Cadherins at cell-autonomous membrane contacts control macropinocytosis.
J Cell Sci
; 124(Pt 12): 2013-20, 2011 Jun 15.
Article
em En
| MEDLINE
| ID: mdl-21610088
ABSTRACT
Cadherins aggregate and stabilize cell-cell junctions through interactions with adjacent cells. In addition, N-cadherin and E-cadherin concentrate at free edges or at the lamellipodia of migrating cells and are found within large vesicles called macropinosomes, which develop from membrane ruffles. The binding properties of cadherins have not previously been associated with the localization of cadherins at membrane ruffles; however, we report that the dorsal, ventral and lateral membrane contacts that occur as a result of the overlap of membrane ruffles aggregate N-cadherin, and that both N-cadherin and E-cadherin promote macropinosome closure and fluid-phase uptake in macropinosomes. These data reveal a previously unsuspected function for cadherin-mediated cell-cell adhesion molecules in the closure of cell-autonomous membrane contacts at membrane ruffles, resulting in macropinocytosis.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Pinocitose
/
Caderinas
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Comunicação Celular
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article