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Induction of myeloma-specific cytotoxic T lymphocytes responses by natural killer cells stimulated-dendritic cells in patients with multiple myeloma.
Nguyen-Pham, Thanh-Nhan; Im, Chang-Min; Nguyen, Truc-Anh Thi; Lim, Mi-Seon; Hong, Cheol Yi; Kim, Mi-Hyun; Lee, Hyun Ju; Lee, Youn-Kyung; Cho, Duck; Ahn, Jae-Sook; Yang, Deok-Hwan; Kim, Yeo-Kyeoung; Chung, Ik-Joo; Kim, Hyeoung-Joon; Lee, Je-Jung.
Afiliação
  • Nguyen-Pham TN; Research Center for Cancer Immunotherapy, Chonnam National University Hwasun Hospital, Jeollanamdo, Hwasun, Republic of Korea.
Leuk Res ; 35(9): 1241-7, 2011 Sep.
Article em En | MEDLINE | ID: mdl-21612823
The interaction between dendritic cells (DCs) and natural killer (NK) cells plays a key role in inducing DC maturation for subsequent T-cell priming. We investigated to generate potent DCs by stimulated with NK cells to induce myeloma-specific cytotoxic T lymphocytes (CTLs). NK cells-stimulated-DCs exhibited high expression of costimulatory molecules and high production of IL-12p70. These DCs induce high potency of Th1 polarization and exhibit a high ability to generate myeloma-specific CTLs responses. These results suggest that functionally potent DCs can be generated by stimulation with NK cells and may provide an effective source of DC-based immunotherapy in multiple myeloma.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Células Dendríticas / Células Matadoras Naturais / Ativação Linfocitária / Linfócitos T Citotóxicos / Mieloma Múltiplo Tipo de estudo: Evaluation_studies Limite: Humans Idioma: En Ano de publicação: 2011 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Células Dendríticas / Células Matadoras Naturais / Ativação Linfocitária / Linfócitos T Citotóxicos / Mieloma Múltiplo Tipo de estudo: Evaluation_studies Limite: Humans Idioma: En Ano de publicação: 2011 Tipo de documento: Article