[Relationship between MnSOD polymorphisms and susceptibility of chronic poisoning exposed to manganism occupationally].
Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi
; 29(3): 206-8, 2011 Mar.
Article
em Zh
| MEDLINE
| ID: mdl-21619820
ABSTRACT
OBJECTIVE:
To study the relationship between polymorphisms of MnSOD and the susceptibility of chronic poisoning exposed to manganism occupationally.METHODS:
In a study of case-control, genotypes were determined by PCR-RFLP in 164 patients with chronic occupational mangamism poisoning and 328 controls with age- and sex-matched for MnSOD 9Ala-Val.RESULTS:
There was a significant difference in the frequency of MnSOD 9Ala-Val at V locus mutant allele between cases and controls (χ(2) = 15.225, P < 0.01, 95%CI = 1.43 â¼ 3.00). Individuals with the genotype VV had a 1.30 of risk increase of occupational chronic manganism poisoning compared with the the genotype AV or AA (OR = 2.30, 95%CI = 1.52 â¼ 3.49, P < 0.05).CONCLUSION:
The MnSOD polymorphisms may be related with the susceptibility to chronic occupational manganism poisoning, the risk of chronic occupational manganism poisoning increases in carriers with genotype VV at MnSOD 9Ala-Val locus.
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Base de dados:
MEDLINE
Assunto principal:
Superóxido Dismutase
/
Predisposição Genética para Doença
/
Intoxicação por Manganês
/
Doenças Profissionais
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
Limite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
Zh
Ano de publicação:
2011
Tipo de documento:
Article