[Observation on therapeutic alliance with UDCA and glucocorticoids in AIH-PBC overlap syndrome].
Zhonghua Gan Zang Bing Za Zhi
; 19(5): 334-9, 2011 May.
Article
em Zh
| MEDLINE
| ID: mdl-21645439
ABSTRACT
OBJECTIVE:
To observe the efficacy of ursodeoxycholic acid (UDCA) combined with glucocorticoids in the treatment of autoimmune hepatitis-primary biliary cirrhosis (AIH-PBC) overlap syndrome.METHODS:
19 patients with AIH-PBC overlap syndrome were divided randomly into two groups initiate combined group and initiate UDCA-monotherapy group. Biochemical responses and pathological features before and after treatment were analyzed retrospectively with student's t test, Wilcoxon rank sum test and Fisher's exact method.RESULTS:
In the initiate combination group, biochemical responses in terms of AIH features (ALT decline to normal, IgG is less than or equal to 16 g/L) and PBC features (ALP decline ≥ 40% or to normal) were achieved. In UDCA-monotherapy group, no statistical difference existed in biochemical responses before adding glucocorticoids, whereas the levels of ALT, AST, GLB and IgG decreased significantly when combined with glucocorticoids. No statistical difference of rates of biochemical responses eixted between the two groups, whereas variance could be seen in different pathological stages. Alleviation of inflammatory infiltration after therapy appeared in 3 patients.CONCLUSION:
Combination therapy of UDCA with glucocorticoids could be suitable for AIH-PBC overlap syndrome. Early treatment is of benefit for achieving better biochemical response and pathological improvement.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Ácido Ursodesoxicólico
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Hepatite Autoimune
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Glucocorticoides
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Cirrose Hepática Biliar
Tipo de estudo:
Clinical_trials
Limite:
Adult
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Female
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Humans
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Male
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Middle aged
Idioma:
Zh
Ano de publicação:
2011
Tipo de documento:
Article