Tolerability and efficacy of house dust mite AIT.
Allergy
; 66 Suppl 95: 55-6, 2011 Jul.
Article
em En
| MEDLINE
| ID: mdl-21668857
ABSTRACT
Sublingual immunotherapy based on grass pollen allergy immunotherapy tablets is an efficacious and well-tolerated treatment for rhinoconjunctivitis, and subcutaneous house dust mite (HDM) immunotherapy is effective against allergic asthma. Three studies have investigated a new ALK tablet for HDM allergy two studies on tolerability in adults and children, and one on efficacy and safety in adults and adolescents with asthma. Treatment was well tolerated, mainly with mild-to-moderate local reactions pertaining to the administration site, such as temporary oral pruritus. The primary efficacy endpoint was a significant reduction in inhaled corticosteroid dose compared to baseline after 1 year of daily treatment. A positive therapeutic effect on asthma was demonstrated by a reduction of more than 80 µg/day inhaled budesonide for a group receiving six developmental units daily compared to the placebo group.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Asma
/
Conjuntivite Alérgica
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Alérgenos
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Dessensibilização Imunológica
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Pyroglyphidae
Tipo de estudo:
Clinical_trials
Limite:
Adolescent
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Adult
/
Animals
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Child
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Child, preschool
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Humans
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article