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New adipocytokines (vaspin, apelin, visfatin, adiponectin) levels in children treated with valproic acid.
Meral, Cihan; Cekmez, Ferhat; Vurucu, Sebahattin; Tascilar, Emre; Pirgon, Ozgur; Canpolat, F Emre; Ipcioglu, Osman Metin; Aydemir, Gokhan; Aydinoz, Secil.
Afiliação
  • Meral C; Department of Pediatrics, GATA Medical Faculty, Istanbul.
Eur Cytokine Netw ; 22(2): 118-22, 2011 Jun.
Article em En | MEDLINE | ID: mdl-21669562
ABSTRACT

AIM:

To investigate the relationship between the newly discovered adipocytokines and increasing body weight (paralleled by increased insulin resistance), and antiepileptic drug therapy with valproic acid (VPA). DESIGN AND

METHODS:

44 children with idiopathic, generalized epilepsy treated with valproic acid (VPA), and 40 control group children were included in this study.

RESULTS:

Both the VPA-treated group and the control group showed no significant difference in terms of age, total cholesterol and LDL-cholesterol. Subjects in the VPA group had significantly higher BMI-SDS than control subjects (2.3±0.15 vs -0.04±0.8, p<0.001). HOMA-IR, apelin and visfatin levels were significantly increased (4.95±2.07 vs 1.46 vs 0.6, p<0.001; 2.21±1.14 vs 0.57±0.15, p<0.001; 31±12 vs 18.4±10.4, p<0.001; respectively), and adiponectin levels were significantly lower in the VPA group (2.02±1.03 vs 12.4±6.1, p<0.001). Triglyceride levels were significantly increased (126±70 vs 80±40 mg/dL, p=0.001), and HDL-cholesterol levels were significantly lower in the VPA group. Vaspin levels were higher in the VPA group than the control group, but the difference was not significant.

CONCLUSION:

Based on the findings of this study, apelin, visfatin and adiponectin levels may be considered as potential regulators of glucose and fat metabolism during valproic acid therapy.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Serpinas / Ácido Valproico / Peptídeos e Proteínas de Sinalização Intercelular / Adiponectina / Adipocinas / Nicotinamida Fosforribosiltransferase / Anticonvulsivantes Limite: Adolescent / Child / Female / Humans / Male Idioma: En Ano de publicação: 2011 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Serpinas / Ácido Valproico / Peptídeos e Proteínas de Sinalização Intercelular / Adiponectina / Adipocinas / Nicotinamida Fosforribosiltransferase / Anticonvulsivantes Limite: Adolescent / Child / Female / Humans / Male Idioma: En Ano de publicação: 2011 Tipo de documento: Article