[Chromosomal location of nonsyndromic cleft lip with or without palates for two multiplex families].
Beijing Da Xue Xue Bao Yi Xue Ban
; 43(3): 333-7, 2011 Jun 18.
Article
em Zh
| MEDLINE
| ID: mdl-21681258
ABSTRACT
OBJECTIVE:
To find chromosome region closely linked to nonsyndromic cleft lip with or without palates (NSCL±P) by genome-wide scan and linkage analysis for two multiplex families.METHODS:
Whole-genome scan and fine genome scan were used to analyse multiplex families members, and parametric, nonparametric and interaction statistical analysis software to determine which chromosomal section was linked to the genetic disease.RESULTS:
Both parametric and nonparametric linkage scores increased by a big margin over the initial linkage scores on 1q32.2-41. Although parametric results were not significant, nonparametric linkage gave a strong evidence for a candidate region on chromosome 2p25.1-24.2. The multiplicative model gave the strongest evidence for interaction in 1q32.2-41 and 2p25.1-24.2.CONCLUSION:
Parametric and nonparametric linkage analyses for 2 NSCL±P multiplex families show that there may be candidate regions on chromosome 1q32.2-41 and 2p25.1-24.2.The two regions of 1q32.2-41 and 2p25.1-24.2 may contribute to NSCL±P risks with interaction.
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Base de dados:
MEDLINE
Assunto principal:
Linhagem
/
Fenda Labial
/
Fissura Palatina
/
Estudo de Associação Genômica Ampla
Tipo de estudo:
Prognostic_studies
Limite:
Female
/
Humans
/
Male
País como assunto:
Asia
Idioma:
Zh
Ano de publicação:
2011
Tipo de documento:
Article