SAR studies of 9-norbornylpurines as Coxsackievirus B3 inhibitors.
Bioorg Med Chem Lett
; 21(14): 4271-5, 2011 Jul 15.
Article
em En
| MEDLINE
| ID: mdl-21684160
ABSTRACT
Coxsackievirus and related enteroviruses are important human pathogens that cause various diseases with clinical manifestations ranging from trivial flu-like syndromes to dangerous or even fatal diseases such as myocarditis, meningitis and encephalitis. Here, we report on our continuous SAR study focused on 9-(bicyclo[2.2.1]hept-2-yl)-9H-purines as anti-enteroviral inhibitors. The purine moiety was modified at positions 2, 6 and 8. Several analogues inhibited Coxsackievirus B3 as well as other enteroviruses at low-micromolar concentrations. The 6-chloropurine derivative was confirmed as the most active compound in this series.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Antivirais
/
Purinas
/
Enterovirus
Limite:
Animals
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article