[From genetics to genomics in the rational design of new Mycobacterium tuberculosis vaccines]. / De la genética a la genómica en el diseño de nuevas vacunas contra la tuberculosis.
Enferm Infecc Microbiol Clin
; 29(8): 609-14, 2011 Oct.
Article
em Es
| MEDLINE
| ID: mdl-21684635
ABSTRACT
Tuberculosis (TB) is an infectious disease affecting people from all ages all over the world. It is estimated that one third of the world population lives infected with the causal agent Mycobacterium tuberculosis. Despite availability and systematic administration of BCG vaccine in endemic areas, TB transmission remains elusive to control, partly because BGC efficacy has been shown to have wide variability (0-80%). Such variability in protection is attributed to factors including the BCG strain used for immunization, pre-existing exposure to environmental saprophytic Mycobacterium species, and host genetic factors. In this context, efforts regarding to re-engineering BCG vaccines with the ability to prevent latent TB reactivation, providing long lasting protection, and devoid from collateral effects in immunosuppressed people are urgent. In this work we review the actual molecular «gene-by-gene¼ strategies aimed at generating BCG alternatives, and discuss the urgent necessity of high throughput technology methods for a rational design for a new TB vaccine.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Vacinas contra a Tuberculose
/
Mycobacterium tuberculosis
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
Es
Ano de publicação:
2011
Tipo de documento:
Article