Cardiovagal autonomic function in HIV-infected patients with unsuppressed HIV viremia.
HIV Clin Trials
; 12(3): 141-50, 2011.
Article
em En
| MEDLINE
| ID: mdl-21684854
ABSTRACT
PURPOSE:
HIV infection has been implicated in dysregulation of the autonomic nervous system.METHOD:
Cross-sectional study examining the relationship between the presence of persistent detectable HIV viral load with autonomic function, measured by heart rate variability (HRV). Non-virologic suppression (NVS) was defined as having a detectable viral load for at least 3 months prior to autonomic function testing. HRV was measured during the following 4 maneuvers resting and paced respirations and sustained handgrip and tilt. Inferences on parasympathetic and sympathetic modulations were determined by analyzing time and frequency domains of HRV.RESULTS:
57 participants were enrolled in 3 groups 22 were HIV-infected participants with HIV virologic suppression (VS; undetectable HIV viral load), 9 were HIV-infected participants who had NVS, and 26 were HIV seronegative controls. There were lower time domain parameters in the HIV-infected group as a whole compared to controls. There were no significant differences in time domain parameters among HIV-infected participants. There were no differences in frequency domain parameters during any of the maneuvers between controls and all HIV-infected participants, nor between the NVS and VS groups.CONCLUSION:
There were differences in autonomic function between HIV-infected individuals and HIV seronegative controls, but not between the NVS and VS groups.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Doenças do Sistema Nervoso Autônomo
/
Viremia
/
Infecções por HIV
Tipo de estudo:
Observational_studies
/
Prevalence_studies
/
Risk_factors_studies
Limite:
Adult
/
Female
/
Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article