Synergistic effect of antituberculosis drugs and azoles in vitro against Histoplasma capsulatum var. capsulatum.
Antimicrob Agents Chemother
; 55(9): 4482-4, 2011 Sep.
Article
em En
| MEDLINE
| ID: mdl-21690286
ABSTRACT
This study evaluated in vitro interactions of antituberculosis drugs and triazoles against Histoplasma capsulatum. Nine drug combinations, each including an antituberculosis drug (isoniazid, pyrazinamide, or ethambutol) plus a triazole (itraconazole, fluconazole, or voriconazole), were tested against both growth forms of H. capsulatum. Stronger synergistic interactions were seen in isoniazid or pyrazinamide plus triazoles for the mold form and ethambutol plus voriconazole for the yeast-like form. Further studies should evaluate these combinations in vivo.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Histoplasma
/
Antituberculosos
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article