Increase in lactate dehydrogenase isoenzyme-1 in plasma in pediatric malignancy.
Clin Chem
; 36(9): 1683-5, 1990 Sep.
Article
em En
| MEDLINE
| ID: mdl-2170062
ABSTRACT
We investigated 28 cases of pediatric malignancy in which total lactate dehydrogenase (LD, EC 1.1.1.27) activities were increased and isoenzyme LD-1 exceeded LD-2 (flipped pattern). Of these, 11 had a flipped pattern at presentation and 17 showed a flipped pattern during chemotherapy. Those with flipped patterns at presentation were four with germ-cell tumors, one with acute lymphocytic leukemia, and six with nephroblastomas (Wilms tumor). Four of five nephroblastoma homogenates contained predominantly LD-1; one revealed a structurally normal LD-1 with normal kinetics. We conclude that an increase in LD with a flipped pattern is common in nephroblastoma and, in addition, may develop in cancer patients treated with chemotherapy.
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Base de dados:
MEDLINE
Assunto principal:
Biomarcadores Tumorais
/
Tumor de Wilms
/
Neoplasias Renais
/
L-Lactato Desidrogenase
Limite:
Child
/
Child, preschool
/
Humans
Idioma:
En
Ano de publicação:
1990
Tipo de documento:
Article