Active site inhibitors protect protein kinase C from dephosphorylation and stabilize its mature form.

Gould, Christine M; Antal, Corina E; Reyes, Gloria; Kunkel, Maya T; Adams, Ryan A; Ziyar, Ahdad; Riveros, Tania; Newton, Alexandra C

Gould, Christine M; Antal, Corina E; Reyes, Gloria; Kunkel, Maya T; Adams, Ryan A; Ziyar, Ahdad; Riveros, Tania; Newton, Alexandra C.

Afiliação

Gould CM; Department of Pharmacology, University of California, San Diego, La Jolla, California 92093-0721; Biomedical Sciences Graduate Program, University of California, San Diego, La Jolla, California 92093-0721.
Antal CE; Department of Pharmacology, University of California, San Diego, La Jolla, California 92093-0721; Biomedical Sciences Graduate Program, University of California, San Diego, La Jolla, California 92093-0721.
Reyes G; Department of Pharmacology, University of California, San Diego, La Jolla, California 92093-0721.
Kunkel MT; Department of Pharmacology, University of California, San Diego, La Jolla, California 92093-0721.
Adams RA; Department of Pharmacology, University of California, San Diego, La Jolla, California 92093-0721.
Ziyar A; Department of Pharmacology, University of California, San Diego, La Jolla, California 92093-0721.
Riveros T; Department of Pharmacology, University of California, San Diego, La Jolla, California 92093-0721; Biomedical Sciences Graduate Program, University of California, San Diego, La Jolla, California 92093-0721.
Newton AC; Department of Pharmacology, University of California, San Diego, La Jolla, California 92093-0721. Electronic address: anewton@ucsd.edu.

J Biol Chem ; 286(33): 28922-28930, 2011 Aug 19.

Article em En | MEDLINE | ID: mdl-21715334

Assuntos

Domínio Catalítico/fisiologia; Proteína Quinase C/antagonistas & inibidores; Proteína Quinase C/metabolismo; Inibidores de Proteínas Quinases/farmacologia; Animais; Células COS; Chlorocebus aethiops; Estabilidade Enzimática/efeitos dos fármacos; Estabilidade Enzimática/genética; Humanos; Fosforilação/efeitos dos fármacos; Fosforilação/genética; Proteína Quinase C/química; Proteína Quinase C/genética; Proteínas Serina-Treonina Quinases/química; Proteínas Serina-Treonina Quinases/genética; Proteínas Serina-Treonina Quinases/metabolismo; Piruvato Desidrogenase Quinase de Transferência de Acetil

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteína Quinase C / Domínio Catalítico / Inibidores de Proteínas Quinases Limite: Animals / Humans Idioma: En Ano de publicação: 2011 Tipo de documento: Article

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