Pseuduvarines A and B, two new cytotoxic dioxoaporphine alkaloids from Pseuduvaria rugosa.
Chem Pharm Bull (Tokyo)
; 59(7): 896-7, 2011.
Article
em En
| MEDLINE
| ID: mdl-21720044
ABSTRACT
Pseuduvarines A (1) and B (2), two new dioxoaporphine alkaloids with an amino moiety, were isolated from the stem bark of Pseuduvaria rugosa and their structures were elucidated by combination of 2D-NMR spectroscopic analysis. Pseuduvarines A (1) and B (2) showed cytotoxicity against MCF7, HepG2, and HL-60 (1 IC50, 0.9, 21.7, and >50.0 µM, respectively, 2 IC50 >50.0, 15.7, and 12.4 µM, respectively).
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Base de dados:
MEDLINE
Assunto principal:
Aporfinas
/
Annonaceae
/
Alcaloides
/
Antineoplásicos Fitogênicos
Limite:
Humans
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article