Thiazolidinediones regulate adipose lineage dynamics.
Cell Metab
; 14(1): 116-22, 2011 Jul 06.
Article
em En
| MEDLINE
| ID: mdl-21723509
ABSTRACT
White adipose tissue regulates metabolism; the importance of this control is highlighted by the ongoing pandemic of obesity and associated complications such as diabetes, atherosclerosis, and cancer. White adipose tissue maintenance is a dynamic process, yet very little is known about how pharmacologic stimuli affect such plasticity. Combining in vivo lineage marking and BrdU labeling strategies, we found that rosiglitazone, a member of the thiazolidinedione class of glucose-lowering medicines, markedly increases the evolution of adipose progenitors into adipocytes. Notably, chronic rosiglitazone administration disrupts the adipogenic and self-renewal capacities of the stem cell compartment and alters its molecular characteristics. These data unravel unknown aspects of adipose dynamics and provide a basis to manipulate the adipose lineage for therapeutic ends.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Tiazolidinedionas
/
Tecido Adiposo Branco
Limite:
Animals
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article