Differential effects of the adenovirus E1A oncogene on members of the AP-1 transcription factor family.
Mol Cell Biol
; 10(11): 5857-64, 1990 Nov.
Article
em En
| MEDLINE
| ID: mdl-2172787
ABSTRACT
The adenovirus early region 1A (E1A) oncogene interferes with the expression level and activity of the AP-1 transcription factor family. E1A abolished the transactivating function of AP-1 (Jun/Fos), which binds to the 12-O-tetradecanoylphorbol-13-acetate-responsive element of the collagenase gene (collTRE). In contrast, the activity of another member of the AP-1 family that binds to the c-junTRE was not repressed. The mRNA expression of the c-jun gene was, in fact, strongly elevated in various cell types expressing the E1A gene of either adenovirus type 5 (Ad5) or Ad12. The regulation of the junB gene by adenovirus E1A, on the other hand, depended both on the cell type and on the transforming adenovirus serotype. The fact that E1A-induced alterations in the repertoire of AP-1 transcription factors depend on its transforming domain in conserved region 1 suggests that the effects are relevant for the transformation process.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Oncogenes
/
Fatores de Transcrição
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Transformação Celular Neoplásica
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Adenovírus Humanos
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Proteínas Oncogênicas Virais
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Proteínas de Ligação a DNA
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
1990
Tipo de documento:
Article