Flueggines A and B, two new dimeric indolizidine alkaloids from Flueggea virosa.
Org Lett
; 13(15): 3888-91, 2011 Aug 05.
Article
em En
| MEDLINE
| ID: mdl-21728296
ABSTRACT
Two unprecedented C,C-linked dimeric indolizidine alkaloids, flueggines A (1) and B (2), were isolated from the twigs and leaves of Flueggea virosa. The structures and absolute configurations were elucidated by means of NMR, single-crystal X-ray diffraction, and CD analyses. Compound 1 is the first example of Securinega alkaloids bearing an isoxazolidine ring, the plausible biogenetic pathway of which is also proposed. Compound 2 exhibited growth inhibitory activity against MCF-7 and MDA-MB-231 human breast cancer cells.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Magnoliopsida
/
Alcaloides
/
Indolizidinas
/
Indolizinas
Limite:
Humans
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article