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Olfactory memory is impaired in a triple transgenic model of Alzheimer disease.
Cassano, Tommaso; Romano, Adele; Macheda, Teresa; Colangeli, Roberto; Cimmino, Concetta Stefania; Petrella, Antonio; LaFerla, Frank M; Cuomo, Vincenzo; Gaetani, Silvana.
Afiliação
  • Cassano T; Department of Biomedical Sciences, University of Foggia, Foggia, 71100, Italy. tommaso.cassano@gmail.com
Behav Brain Res ; 224(2): 408-12, 2011 Oct 31.
Article em En | MEDLINE | ID: mdl-21741995
ABSTRACT
Olfactory memory dysfunctions were investigated in the triple-transgenic murine model of Alzheimer's disease (3 × Tg-AD). In the social transmission of food preference test, 3 × Tg-AD mice presented severe deficits in odor-based memory, without gross changes in general odor-ability. Aß and tau immunoreactivity was not observed in the primary processing regions for odor, the olfactory bulbs (OBs), whereas marked immunostaining was present in the piriform, entorhinal, and orbitofrontal cortex, as well as in the hippocampus. Our results suggest that the impairment in olfactory-based information processing might arise from degenerative mechanisms mostly affecting higher cortical regions and limbic areas, such as the hippocampus.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Olfato / Doença de Alzheimer / Memória Limite: Animals / Humans Idioma: En Ano de publicação: 2011 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Olfato / Doença de Alzheimer / Memória Limite: Animals / Humans Idioma: En Ano de publicação: 2011 Tipo de documento: Article