Increasing the time of exposure to aerosol measles vaccine elicits an immune response equivalent to that seen in 9-month-old Mexican children given the same dose subcutaneously.
J Infect Dis
; 204(3): 426-32, 2011 Aug 01.
Article
em En
| MEDLINE
| ID: mdl-21742842
ABSTRACT
BACKGROUND:
A 30-second aerosol measles vaccination successfully primes children 12 months of age and older but is poorly immunogenic when given to 9-month-old children. We examined the immune responses when increasing the duration to aerosol exposure in 9-month-olds.METHODS:
One hundred and thirteen healthy 9-month-old children from Mexico City were enrolled; 58 received aerosol EZ measles vaccine for 2.5 minutes and 55 subcutaneously. Measles-specific neutralizing antibodies and cellular responses were measured before and at 3 and 6 months postimmunization.RESULTS:
Adaptive immunity was induced in 97% after aerosol and 98% after subcutaneous administration. Seroconversion rates and GMCs were 95% and 373 mIU/mL (95% confidence interval [CI], 441-843) following aerosol vaccination and 91% and 306 mIU/mL (95% CI, 367-597) after subcutaneous administration at 3 months. The percentage of children with a measles-specific stimulation index ≥3 was 45% and 60% in the aerosol versus 55% and 59% in the subcutaneous group at 3 and 6 months, respectively. CD8 memory cell frequencies were higher in the aerosol group at 3 months compared with the subcutaneous group. Adverse reactions were comparable in both groups.CONCLUSIONS:
Increasing exposure time to aerosol measles vaccine elicits immune responses that are comparable to those seen when an equivalent dose is administered by the subcutaneous route in 9-month-old infants.
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Vacina contra Sarampo
/
Vacinação
/
Anticorpos Antivirais
Tipo de estudo:
Clinical_trials
Limite:
Female
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Humans
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Infant
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Male
País como assunto:
Mexico
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article