A novel form of presynaptic CaMKII-dependent short-term potentiation between Lymnaea neurons.
Eur J Neurosci
; 34(4): 569-77, 2011 Aug.
Article
em En
| MEDLINE
| ID: mdl-21749498
ABSTRACT
Short-term plasticity is thought to form the basis for working memory, the cellular mechanisms of which are the least understood in the nervous system. In this study, using in vitro reconstructed synapses between the identified Lymnaea neuron visceral dorsal 4 (VD4) and left pedal dorsal 1 (LPeD1), we demonstrate a novel form of short-term potentiation (STP) which is 'use'- but not time-dependent, unlike most previously defined forms of short-term synaptic plasticity. Using a triple-cell configuration we demonstrate for the first time that a single presynaptic neuron can reliably potentiate both inhibitory and excitatory synapses. We further demonstrate that, unlike previously described forms of STP, the synaptic potentiation between Lymnaea neurons does not involve postsynaptic receptor sensitization or presynaptic residual calcium. Finally, we provide evidence that STP at the VD4-LPeD1 synapse requires presynaptic calcium/calmodulin dependent kinase II (CaMKII). Taken together, our study identifies a novel form of STP which may provide the basis for both short- and long-term potentiation, in the absence of any protein synthesis-dependent steps, and involve CaMKII activity exclusively in the presynaptic cell.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Terminações Pré-Sinápticas
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Transmissão Sináptica
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Proteína Quinase Tipo 2 Dependente de Cálcio-Calmodulina
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Plasticidade Neuronal
Limite:
Animals
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article