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Subclinical lithium neurotoxicity: correlation of neural conduction abnormalities and serum lithium level in manic-depressive patients with lithium treatment.
Chang, Y C; Lin, H N; Deng, H C.
Afiliação
  • Chang YC; Department of Neurology, National Taiwan University Hospital, Taipei, R.o.C.
Acta Neurol Scand ; 82(2): 82-6, 1990 Aug.
Article em En | MEDLINE | ID: mdl-2175146
Nerve conduction velocities (NCVs) and multimodality evoked potentials were studies in 28 manic-depressive patients under lithium prophylaxis with serum lithium levels between 0.320 and 0.980 mEq/L. Slowing of motor and sensory NCVs and prolonged central neural conduction times obtained from somatosensory and brainstem auditory evoked potentials were found to correlate with serum lithium levels. Lithium-induced changes in cell membrane conductivity and in the synaptic transmission are considered responsible for the neurotoxic effects of lithium.
Assuntos
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Base de dados: MEDLINE Assunto principal: Transtorno Bipolar / Potenciais Evocados / Lítio / Condução Nervosa Tipo de estudo: Diagnostic_studies / Observational_studies / Prognostic_studies / Screening_studies Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 1990 Tipo de documento: Article
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Base de dados: MEDLINE Assunto principal: Transtorno Bipolar / Potenciais Evocados / Lítio / Condução Nervosa Tipo de estudo: Diagnostic_studies / Observational_studies / Prognostic_studies / Screening_studies Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 1990 Tipo de documento: Article