Acid-base jointly promoted copper(I)-catalyzed azide-alkyne cycloaddition.
J Org Chem
; 76(16): 6832-6, 2011 Aug 19.
Article
em En
| MEDLINE
| ID: mdl-21793533
ABSTRACT
In this novel acid-base jointly promoted CuAAC, the combination of CuI/DIPEA/HOAc was developed as a highly efficient catalytic system. The functions of DIPEA and HOAc have been assigned, and HOAc was recognized to accelerate the conversions of the C-Cu bond-containing intermediates and buffer the basicity of DIPEA. As a result, all drawbacks occurring in the popular catalytic system CuI/NR(3) were overcome easily.
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MEDLINE
Idioma:
En
Ano de publicação:
2011
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Article